Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis

Figure 2 Marker genes for hepatic stellate cells (HSCs). Expression profiles of the whole liver and in vitro cultured isolated HSCs were obtained using a rat genome U34A array (Affymetrix). Gene markers for HSCs are listed. For analysis of HSCs in the whole liver, expression intensities are given for d 0, and expression intensity data for d 4, 7, 14, 21 and 28 are shown as ratios to the d 0 expression data. The classification of group1 (2) corresponds to the presence (absence) of up-regulated peak in the acute inflammation phase. For analysis of in vitro cultured HSCs, expression levels for d 0 are also shown, and data for d 4 and 7 are similarly shown as ratios to the expression level on d 0. Italicized values indicate an “absent” call by the Affymetrix software. Bold text indicates the highest ratio in the chronic phase (d 7, 14, 21 and 28).