Severity of ulcerative colitis is associated with a polymorphism at diamine oxidase gene but not at histamine N-methyltransferase gene

Table 4 Phenotypic among UC patients classified as carriers or non-carriers of mutations at the HNMT gene

Phenotypic characteristics	Carriersn = 34	Non-carriersn = 161	OR (95% CI)p value
Male:Female	20:14	91:70	1.10 (0.49-2.49) 0.81
Mean age at diagnosis, yr (range)	35 (6-83)	38 (17-81)	P = 0.24
Mean duration of disease, yr (range)	12.4 (2-39)	11.3 (2-41)	P = 0.11
Family history of IBD, n (%)	8 (23.5%)	35 (21.7%)	1.11 (0.42-2.85) 0.82
Smokers at diagnosis, n (%)	8 (23.5%)	31 (19.3%)	1.29 (0.48-3.36) 0.57
Previous appendectomy, n (%)	2 (5.9%)	6 (3.7%)	1.61 (0.21-9.47) 0.63
Previous tonsillectomy, n (%)	2 (5.9%)	17 (10.5%)	0.53 (0.08-2.57) 0.54
Extent of UC
Extensive, n (%)	15 (44.1%)	64 (39.8%)	1.20 (0.53-2.69) 0.63
Non-extensive, n (%)	19 (55.9%)	97 (60.2%)
Extraintestinal manifestations
Cutaneous, n (%))	6 (17.6%)	19 (11.8%)	1.60 (0.52-4.66) 0.4
Articular, n (%)	15 (44.1%)	47 (29.2%)	1.91 (0.84-4.35) 0.09
Ocular, n (%)	1 (2.9%)	5 (3.1%)	0.95 (0.02-8.86) 1
Hepatic, n (%)	5 (14.7%)	27 (16.8%)	0.86 (0.26-2.60) 0.77
Therapy categories
Immunosuppressants, n (%)	8 (23.5%)	37 (23%)	1.031 (0.39-2.65) P = 0.94
Surgery, n (%)	6 (17.6%)	16 (9.94%)	1.941 (0.62-5.91) 0.20

¹As compared with the remaining patients.