Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells

Figure 8 Evaluation of the role of C/EBP transcription factors in the differentiation of BMSC and ADSC cells. Adenoviral transduction caused a dose-dependent increase in the level of C/EBPβ mRNA, as assessed by real-time PCR analysis (A). Concomitantly, an up-regulation of CYP3A4 was observed which was more significant in ADSCs (B), and was paralleled by a significant down-regulation of the mesenchymal cells marker Thy1 in both BMSC and ADSC (C). Controls were not transduced. Data are shown as a fold increase in the mRNA level compared to the control and normalized by hPBGD. Data are the mean ± SE of 3 different cultures of BMSC and ADSC.