Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer

Figure 5 Apoptosis induction by NVP-AEW541 (mean ± SE, n = 4). A: After HT-29 and HCT-116 cells were incubated with 0.5-10 μmol/L NVP-AEW541 for 24 h, a dose-dependent induction in caspase-3 activation was observed; B: After 72 h of NVP-AEW541 treatment an increased proportion of apoptotic cells measured as subdiploidy was observed in HT-29 cells. ^aP < 0.05 vs untreated controls.