Expressions of sonic hedgehog, patched, smoothened and Gli-1 in human intestinal stromal tumors and their correlation with prognosis

Table 1 Aberrant expression of Hedgehog pathway signaling proteins in intestinal stromal tumors n (%)

			Shh		Ptc		Smo		Gli-1
		n	+	-	+	-	+	-	+	-
GIST		31	18 (58.1)	13 (41.9)	24 (77.4)	7 (22.6)	25 (80.6)	6 (19.4)	18 (58.1)	13 (41.9)
I	GIST, M	7 (22.6)	4 (57.1)	3 (42.9)	5 (71.4)	2 (28.6)	6 (85.7)	1 (14.3)	4 (57.1)	3 (42.9)
	GIST, N	8 (25.8)	5 (62.5)	3 (37.5)	5 (62.5)	3 (37.5)	4 (50.0)	4 (50.0)	3 (37.5)	5 (62.5)
	GIST, UN	16 (51.6)	9 (56.3)	7 (43.8)	14 (87.5)	2 (12.5)	15 (93.8)	1 (6.3) c	11 (68.8)	5 (31.3)
II	GIST, EP	5 (16.1)	3 (60.0)	2 (40.0)	4 (80.0)	1 (20.0)	3 (60.0)	2 (40.0)	2 (40.0)	3 (60.0)
	GIST, MIX	3 (9.7)	2 (66.7)	1 (33.3)	2 (66.7)	1 (33.3)	3 (100)	0 (0.0)	2 (66.7)	1 (33.3)
	GIST, SP	23 (74.2)	13 (56.5)	10 (43.4)	17 (73.9)	6 (26.1)	19 (82.6)	4 (17.4)	14 (60.9)	9 (39.1)
Leiomyoma		13	12 (92.3)	1 (7.7) a	12 (92.3)	1 (7.7)	9 (69.2)	4 (30.8)	12 (92.3)	1 (7.7) a
Schwannoma		6	5 (83.3)	1 (16.7)	5 (83.3)	1 (16.7)	5 (83.3)	1 (16.7)	6 (100)	0 (0.0)

n (%): Tumor cases followed by percentage (%) of total cases.

^aP < 0.05 between Leiomyoma and GIST in Shh or Gli-1;

^cP < 0.05 between GIST, UN and GIST, N.