Promoter hypomethylation and reactivation of MAGE-A1 and MAGE-A3 genes in colorectal cancer cell lines and cancer tissues

Table 2 Summary of expressions, promoter methylation status and clinical associations of the MAGE-A1 and MAGE-A3 genes in 32 colorectal cancer cell lines and 87 colorectal cancer tissues

	% of expression			% of hypomethylation
	MAGE-A1		MAGE-A3	MAGE-A1		MAGE-A3
Cancer cell lines	59		66	81		81
Cancer tissues	NT1		NT	43		77
Normal tissues2	NT		NT	2		6
	MAGE-A1 hypomethylation			MAGE-A3 hypomethylation
	+	-	P	+	-	P
Location
Proximal	14 (31.1%)	31(68.9%)		34 (75.6%)	11 (24.4%)
Distal	17 (56.7%)	13(43.3%)	0.028	26 (86.7%)	4 (13.3%)	0.239
Sex
Male	17 (30.9%)	38(69.1%)		38 (69.1%)	17 (30.9%)
Female	20 (62.5%)	12(18.4%)	0.004	29 (90.6%)	3 (9.4%)	0.021

¹Not tested;

²Corresponding normal tissues of cancer tissues; +: Represent hypomethylation of MAGE genes; -: Represent no hypomethylation of MAGE genes.