Effect of Fructus Psoraleae on motility of gallbladder isolated smooth muscle strips from guinea pigs

Table 1 Effect of Fructus Psoraleae on resting tension (g) of isolated gallbladder muscle strip after pretreated with antagonists (means ± SD)

Resting tension (g)	Fructus Psoraleae (g/L)
	0	0.1	0.3	1	3	10	20
Pso	0.00 ± 0.00	0.00 ± 0.00	0.02 ± 0.04	0.09 ± 0.04	0.24 ± 0.08a	0.88 ± 0.35d	1.37 ± 0.41d
Ben + Pso	0.00 ± 0.00	0.00 ± 0.00	0.02 ± 0.04	0.07 ± 0.06	0.14 ± 0.08c	0.29 ± 0.17bh	0.45 ± 0.38dh
Phe + Pso	0.00 ± 0.00	0.00 ± 0.00	0.01 ± 0.04	0.07 ± 0.07	0.17 ± 0.08b	0.46 ± 0.11dh	0.89 ± 0.22df
4-DAMP + Pso	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00	0.01 ± 0.04f	0.09 ± 0.07f	0.30 ± 0.18dh	0.70 ± 0.35dh
Hex + Pso	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00	0.05 ± 0.08	0.16 ± 0.14a	0.42 ± 0.20ch	0.94 ± 0.23cd
Ido + Pso	0.00 ± 0.00	0.00 ± 0.00	0.01 ± 0.02	0.09 ± 0.06	0.21 ± 0.12a	0.71 ± 0.23d	1.31 ± 0.41d
Iso + Pso	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00	0.01 ± 0.03f	0.10 ± 0.06f	0.38 ± 0.19ch	0.94 ± 0.26cd

^aP < 0.05,

^bP < 0.01,

^dP < 0.001 vs control (under 1-g initial load the gallbladder spontaneous contraction when Fructus Psoraleae was 0 g/L ). The resting tension of each strip in control was 0 (n = 8).

^cP < 0.05,

^fP < 0.01,

^hP < 0.001 vs Fructus Psoraleae (the resting tension of adding each concentration of Fructus Psoraleae) (n = 8). Pso: Fructus Psoraleae; Ben: Benzhydramine; Phe: Phentolamine; Hex: Hexamethonium; Ido: Idomethine; Iso: Verapamil.