Prolonged exposure of colon cancer cells to the epidermal growth factor receptor inhibitor gefitinib (Iressa™) and to the antiangiogenic agent ZD6474: Cytotoxic and biomolecular effects

Table 1 AUC and retention time of gefitinib or ZD6474 following incubation for 7 d at 37°C, by HPLC analysis

Drug	Medium	Concentration (µmol/L)	Retentiontime (min)	AUC
Gefitinib	DMSO	100	2.47 ± 0.03	1.30 ± 0.20
	Complete medium	100	2.52 ± 0.05	1.27 ± 0.16
ZD6474	DMSO	100	1.75 ± 0.02	0.88 ± 0.08
	Complete medium	100	1.71 ± 0.04	0.86 ± 0.10