Gut hormones, and short bowel syndrome: The enigmatic role of glucagon-like peptide-2 in the regulation of intestinal adaptation

Figure 3 A: GLP-2 stimulation of the G_s-Coupled Receptor induced cell proliferation. The proposed GLP-2 /GLP-2R signaling pathway as characterized in cells that were transfected with the GLP-2R. See section on GLP-2 receptor-activity for description (pages 11-12); B: GLP-2 stimulation of the Gα_i-Coupled Receptor induced cell proliferation. Possible trafficking pathways triggered by GLP-2 in cells that tested negative for the characterized GLP-2R. Potentially, GLP-2 induces divergent signaling pathways which results in an increase in the rate of cell proliferation. See section on GLP-2 receptor-activity for description (pages 11-12).