Gut hormones, and short bowel syndrome: The enigmatic role of glucagon-like peptide-2 in the regulation of intestinal adaptation

Figure 2 An experimental rat model of SBS-induces changes in circulatory GLP-2 levels. The distal regions of the small bowel and/or the large intestine are necessary for GLP-2 production. In these experiments, the entire proximal small bowel was removed; therefore the distal ileum and/or the colon are likely the cells responsible for the production of GLP-2 as all other bowel tissue had been removed. Resected = 90% intestinal resection leaving a 10 cm ileal remnant. CEC = cecetomy + removal of all but 20 cm of jejunum. The remnant jejunum was anastomosed to the ascending colon. ^aP < 0.05 vs cecetomized animals; ^cP < 0.05 vs 90% proximal resected animals that were enterally-fed (10 cm remnant ileum).