NOD2: Ethnic and geographic differences

Table 2 Results of association analysis between NOD2 RAs and other inherited diseases

Disease	Linkage tochromosome16	Ethnicity	Association	Reference
Allergy and atopy	yes	German	yes1	[21]
Behcet’s disease	yes	UK, Turkish and Arab	no2	[27]
Breast cancer with lung cancer FDR3	no	Poland	yes	[18]
Idiopathic pulmonary fibrosis	unknown	Italian	no	[28]
Necrotising enteritis	unknown	France	no4	[29]
Psioratic arthritis	yes	Newfoundland	yes	[30]
Psioratic arthriris	yes	UK	no	[31]
Rheumatoid arthritis	no	USA	no5	[32]
Sarcoidosis	no	Danes	no	[33]
Sarcoidosis	no	United Kingdom	no	[34]
Spondyloarthropathy with chronic gut inflammation	no	Belgium	yes	[20]
Systemic lupus erythematosus	yes	Spain	no	[35]
Type 1 diabetes	yes	Scandinavia	no	[36]
Wegener's granulomatosis	no	North America	no	[37]

¹Both disease and protective associated haplotypes are described;

²Direct sequencing to identify polymorphisms failed to identify association by case-control;

³FDR first degree relative. The association reported occurs only in breast cancer patients who have a first degree relative with lung cancer but not in individuals without;

⁴All exons and exon/intron boundaries of NOD2 were sequenced;

⁵Genoyped for 3 common and a further 12 SNPs in NOD2 with no haplotype association observed.