Multidrug resistance 1 gene in inflammatory bowel disease: A meta-analysis

Table 1 Substrates (S), inhibitors (I-) and inducers (I+) of P-glycoprotein (Modified from ref. 9)

DRUG	S	I-	I+	DRUG	S	I-	I+
Anticancer				Antiviral
Actinomycin D	√			Amprenavir	√		√
Daunorubicin	√			Indinavir	√	√	√
Mitomicyn C	√			Nelfinavir	√	√	√
Mitoxantrone	√			Antibiotics
Vinblastine	√			Claritromycin		√
Vincristine	√			Erythromycin	√	√
Antihypertensive				Levofloxacin	√
Diltiazem	√			Rifampin	√		√
Losartan	√			Tetracycline	√
Nicardipine		√		Antimycotics
Talinolol	±			Itraconazole	√	√
Antiarrhythmics				Ketoconazole		√
Amiodarone		√		Immunosup.
Digoxin	√			Cyclosporine	√	√
Quinidine	√	√		Tacrolimus	√	√
Verapamil	√	√		Methotrexate	√
Glucocorticoids				Antidepressants
Aldosterone	√			Amitriptyline	√
Cortisol	√			Fluoxetine		√
Dexamethasone	√		√	Neuroleptics
Methylprednisolone	√			Chlorpromazine		√
Others				Phenotiazine		√
Colchicine	√			Phenobarbital	√
Dipyridamole		√		Opioids
Loperamide	√			Methadone		√
Progesterone		√		Morphine	√
Spironolactone		√		Antacids
Domperidone	√			Ranitidine	√
Ondansetron	√			Cimetidine	√