Bile acid interactions with cholangiocytes

Figure 2 Membrane recycling of ASBT. Increased cAMP enhances bile acid uptake in cholangiocytes. Under basal conditions, intracellular ASBT resides in an inactive position within the cytoplasm of cholangiocytes as well as on the apical membrane. Increased cAMP results in translocation of ASBT to the apical membrane where it inserts by exocytosis. Once on the apical membrane, ASBT becomes active and mediates absorption of bile acids from bile. Membrane recycling of ASBT is completed by removal of ASBT from the apical membrane by endocytosis.