Nervous and Neuroendocrine regulation of the pathophysiology of cholestasis and of biliary carcinogenesis

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Jun 14, 2006 (publication date) through May 17, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 14, 2006; 12(22): 3471-3480
Published online Jun 14, 2006. doi: 10.3748/wjg.v12.i22.3471

Table 2 Neurotransmitters/neurotrophins affecting cholangi-ocyte biology

Peptide	Receptor	Effect on cholangiocyte biology	Reference
Acetylcholine	M3	Potentiates the effect of secretin. Required for cholangiocyte response to BDL: sustains cholangiocyte proliferation and prevents apoptosis	43, 60, 61, 64, 65
Epinephrine/ Norephinephrine	α₁	Potentiates the effect of secretin	67
Epinephrine/ Norephinephrine	β₁-β₂	Required for cholangiocyte response to BDL: sustains cholangiocyte proliferation and prevents apoptosis	70
Dopamine	D2	Inhibits secretin-induced ductal secretion	73
NGF	TrkA	Secreted by hyperplastic, cholestatic cholangiocytes; sustains the rpoliferative response to BDL	74

Citation: Marzioni M, Fava G, Benedetti A. Nervous and Neuroendocrine regulation of the pathophysiology of cholestasis and of biliary carcinogenesis. World J Gastroenterol 2006; 12(22): 3471-3480
URL: https://www.wjgnet.com/1007-9327/full/v12/i22/3471.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i22.3471