Gastro-protective action of lafutidine mediated by capsaicin-sensitive afferent neurons without interaction with TRPV1 and involvement of endogenous prostaglandins

doi:10.3748/wjg.v12.i19.3031

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May 21, 2006 (publication date) through Apr 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 21, 2006; 12(19): 3031-3037
Published online May 21, 2006. doi: 10.3748/wjg.v12.i19.3031

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Figure 6 Effects of lafutidine and capsaicin on gastric mucosal 6-keto-PGF_1α levels in mice. The animals were given capsaicin (10 mg/kg) po and killed 1 h later. Indomethacin (5 mg/kg) was administered sc 30 min before capsaicin. Gastric mucosal 6-keto-PGF_1α levels were determined by EIA. Data are presented as the mean ± SE from 4-5 rats. ^aP < 0.05 vs control.

Citation: Fukushima K, Aoi Y, Kato S, Takeuchi K. Gastro-protective action of lafutidine mediated by capsaicin-sensitive afferent neurons without interaction with TRPV1 and involvement of endogenous prostaglandins. World J Gastroenterol 2006; 12(19): 3031-3037
URL: https://www.wjgnet.com/1007-9327/full/v12/i19/3031.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i19.3031