Gastro-protective action of lafutidine mediated by capsaicin-sensitive afferent neurons without interaction with TRPV1 and involvement of endogenous prostaglandins

Figure 3 Effects of indomethacin and L-NAME on the protective action of lafutidine or capsaicin against HCl/ethanol-induced gastric lesions in rats. The animals were given 1 mL of HCl/ ethanol (60% ethanol in 150 mmol/L HCl) po and killed 1 h later. Lafutidine (10 mg/kg) or capsaicin (10 mg/kg) was given po 30 min before HCl/ethanol. Indomethacin (5 mg/kg) or L-NAME (20 mg/kg) was administered sc 1 h before HCl/ethanol. Data are presented as the mean ± SE from 6-9 rats. ^aP < 0.05 vs control, ^cP < 0.05 vs saline.