Gastro-protective action of lafutidine mediated by capsaicin-sensitive afferent neurons without interaction with TRPV1 and involvement of endogenous prostaglandins

Figure 1 Effects of lafutidine (A) and capsaicin (B) on HCl/ethanol-induced gastric lesions in rats. The animals were given 1 mL of HCl/ethanol (60% ethanol in 150 mmol/L HCl) po and killed 1 h later. Lafutidine (1-10 mg/kg) and capsaicin (1-10 mg/kg) were administered po 30 min before HCl/ethanol. Ablation of capsaicin-sensitive afferent neurons was achieved by consecutive s.c. injections of capsaicin (total dose of 100 mg/kg) once daily for 3 d 2 wk before the experiment. Data are presented as the mean ± SE from 4-7 rats. ^aP < 0.05, ^cP < 0.05 vs control.