Endoscopic therapies of gastroesophageal reflux disease

Table 1 Endotherapy result comparisons: pooled data

Trial result	ELGP	NDO Plicator	Stretta	Enteryx	Gatekeeper1
HDQRL improvement	55%	70%	65%	70%	74%1
Heartburn improvement	74%	-	61%	71%	-
Off PPI’s
At 1 yr	40%	75%	55%	72%	58%1
At > 2 yr	33%	-	63%	65%	-
≥ 50% reduction in PPI	51%	-	67%	80%	54%1
Quality of life improvement
SF-36 Physical	17%	31%	20%	12%	17%1
SF-36 Mental	None	10%	14%	3%	1.4%1
Time pH < 4 improvement	16%	None	36%	33%	32%1
No. of reflux episode improvement	33%	-	None	31%	45%1
pH normalization	25%	-	-	38%	40%1
LESP improvement	None	None	None	None	None
LES length improvement	None	None	None	None	None
tLESR improvement	Yes	No	Yes	No	No
Healing of esophagitis	None	None	None	None	None
Sham Trial	3-mo FU	Being planned	1-yr FU	Underway	Underway

¹6 mo follow-up. None: Change not statistically significant. All results are at 1-yr follow-up except Gatekeeper. Highlighted cell indicate controversy regarding results but the results mentioned above are the ones shown by the majority of studies.