Helicobacter pylori eradication to prevent gastric cancer: Underlying molecular and cellular mechanisms

Table 2 "p53" mutation in gastric cancers of early stages and precancerous gastric lesions. In gastric cancers of early stages and precancerous gastric lesions, LOH and splicing are merely reported. Abbreviations for mutation: Del: deletion; Ins: insertion; F/S: frame shift. Abbreviations for lesion: EGC: early gastric cancer; AD: adenoma, CA/AD: carcinoma in adenoma; D: dysplasia; IM: intestinal metaplasia; N: mucosa without dysplasia, IM or carcinoma. Data are collected from references 104, 105, 113-118. (Modified from Tsuji et al[119,120])

First author	Year	Case	G:C→A:T	G:C→T:A	A:T→G:C	A:T→C:G	A:T→T:A	G or C	Del	Ins	F/S	Lesions
Yokozaki	1992	1			2	1	1	1				EGC
Tohdo	1993	5			3						1	AD or CA/AD
Uchino	1993	12	10			2		1				EGC
Correa	1994	8	4		3				1			D, IM, or N
Hongyo	1995	9	10					1	1	2		Cancer at stage I
Sakurai	1995	7	4									AD, CA/AD or EGC
Tamura	1995	1	1									AD
Tamura	1995	4	3	2								EGC
Ranzani	1995	18	13	1			1	1	1	2		EGC
Summary			45	3	8	3	2	3	4	4	1
(%)			62	4	11	4	3	4	5	5	1