Cis-hydroxyproline-induced inhibition of pancreatic cancer cell growth is mediated by endoplasmic reticulum stress

Figure 1 Effect of CHP on morphological appearance of DSL6A cell (Phase contrast microscopy, original magnification x200). A: Adherently growing controls; B: Incubation with 10 mmol/L CHP for 24 h caused rounding, followed by detachment of DSL cells; C: Addition of 20 mmol/L L-proline abolished the effects of CHP; D: CHP-treated cells cultured for further 48 h with 20 mmol/L L-proline, resulting in the re-adherence of the cells.