Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU-5 cell line

doi:10.3748/wjg.v12.i1.21

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Jan 7, 2006 (publication date) through Apr 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Gastric Cancer

World J Gastroenterol. Jan 7, 2006; 12(1): 21-28
Published online Jan 7, 2006. doi: 10.3748/wjg.v12.i1.21

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Figure 8 Proposed model of berberine mechanism of action on G2/M arrest and apoptosis in SNU-5 cells. Berberine induced p53 expression that led to the decrease of cyclin B and CDK1 but increase of the expression of cdc25c and Wee1 for G2/M arrest. Berberine induced ROS, Ca²⁺ production and decreased MMP levels led to cytochrome C release and caspase-3 activity, causing apoptosis in SNU-5 cells.

Citation: Lin JP, Yang JS, Lee JH, Hsieh WT, Chung JG. Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU-5 cell line. World J Gastroenterol 2006; 12(1): 21-28
URL: https://www.wjgnet.com/1007-9327/full/v12/i1/21.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i1.21