Effect of rhubarb on contractile response of gallbladder smooth muscle strips isolated from guinea pigs

Table 2 Effect of rhubarb on the contractile amplitude (mm) of isolated guinea pig gallbladder muscle strips after pretreatment with antagonists (mean±SE).

Amplitude (mm)	Rhubarb (g/L)
	0	0.05	0.15	5	15	50	100
Rhubarb	5.2±0.7	4.9±0.7	5.0±0.7	4.8±0.7	4.0±0.5	3.0±0.4a	2.7±0.4c
Phe+Rhu	3.3±0.4	3.2±0.4	3.1±0.4	3.0±0.4	2.9±0.4	2.3±0.4	1.7±0.4c
Hex+Rhu	4.7±0.6	4.5±0.6	4.3±0.6	4.2±0.6	3.8±0.8	3.1±0.5	2.7±0.5a
Atr+Rhu	5.4±0.9	5.3±0.9	5.1±0.8	4.8±0.7	4.5±0.7	3.8±0.6	3.1±0.5a
Iso+Rhu	5.2±0.9	5.1±1.0	4.9±1.0	4.7±0.8	4.4±0.9	3.4±0.6	3.0±0.5

^aP<0.05,

^cP<0.005 vs control (the gallbladder spontaneous mean contraction amplitude under 1-g initial load when rhubarb was 0 g/L) n = 12.