Effect of rhubarb on contractile response of gallbladder smooth muscle strips isolated from guinea pigs

Table 1 Effect of rhubarb on resting tension (g) of isolated guinea pig gallbladder muscle strips after pretreatment with antagonists (mean±SE).

Resting tension (g)	Rhubarb (g/L)
	0	0.05	0.15	5	15	50	100
Rhubarb	0	0.03±0.01	0.09±0.02c	0.20±0.03c	0.48±0.03c	0.46±0.02c	0.40±0.02c
Phe+Rhu	0	0.04±0.01	0.06±0.01e	0.11±0.01cg	0.33±0.05cg	0.30±0.05cg	0.27±0.04cg
Hex+Rhu	0	0.04±0.01	0.08±0.01e	0.17±0.02g	0.39±0.02g	0.40±0.02g	0.35±0.02g
Atr+Rhu	0	0g	0.03±0.01g	0.07±0.01ag	0.22±0.04cg	0.19±0.03cg	0.16±0.01cg
Iso+Rhu	0	0.03±0.01	0.07±0.01c	0.10±0.01ce	0.30±0.01cg	0.28±0.02cg	0.21±0.02cg

^aP<0.05,

^cP<0.005 vs control (the gallbladder spontaneous contraction under 1-g initial load when rhubarb was 0 g/L) n = 12. The resting tension of each strip in control was 0.

^eP<0.05,

^gP<0.005 vs rhubarb (the resting tension of adding each concentration of rhubarb) n = 12.