Loss of heterozygosity: An independent prognostic factor of colorectal cancer

Table 6 Informative markers that influenced three-year DFS in potentially cured colorectal cancer patients (stage I, II, III patients).

Markers	Number of cases	3-yr disease-free survival	P1
Nm23-H1
Non-LOH	68	75	0.266
LOH	28	62
APC
Non-LOH	54	75	0.881
LOH	45	72
Tp53.alu
Non-LOH	29	92	<0.001
LOH	55	51
HPC1
Non-LOH	87	75	0.743
LOH	12	70
D8S254
Non-LOH	39	75	0.03
LOH	31	52
DCC
Non-LOH	27	79	0.042
LOH	45	55
MSH2
Non-LOH	107	73	0.972
LOH	15	75
MLH1
Non-LOH	62	66	0.287
LOH	19	57
Met ONC
Non-LOH	50	72	0.35
LOH	16	64
Tp53.pcr15
Non-LOH	42	76	<0.001
LOH	20	33
MYCL1
Non-LOH	59	71	0.421
LOH	29	65

¹Log-rank test; The markers that had frequency of informative tumors lower than 30% were excluded in the survival analysis.