Loss of heterozygosity: An independent prognostic factor of colorectal cancer

Table 4 Correlation of the clinico-pathological factors with three-year disease-free survival in potentially cured colorectal cancer patients (stage I, II, III patients).

Variables	Number of cases	3-yr disease -free survival	P1
Gender
Male	116	70	0.614
Female	50	75
Preoperative CEA level
<5 ng/mL	80	82	0.003
>5 ng/mL	86	63
TNM stage
I	25	95	<0.001
II	73	84
III	68	47
Lymphovascular permeation
No	129	73	0.091
Yes	37	63
Invasive pattern of tumor
Expansive	45	73	0.517
Infiltrative	121	68
Grade of differentiation
Well	3	100	0.004
Moderate	146	75
Poor	17	48
Mucinous component
<50%	143	72	0.642
>50%	23	68
Microsatellite instability
MSI-H	13	69	0.91
MSS	153	71
LOH status
Low	100	84	<0.001
High	66	50

¹Log-rank test