Overexpression of NK2 inhibits liver regeneration after partial hepatectomy in mice

Figure 2 Liver regeneration and proliferation of hepatocytes after PH. H-E stain of WT mouse liver (A) and NK2 transgenic mouse liver (B) at 48 h after PH. NK2 transgenic mouse liver contained a large amount of intracellular small droplets. Magnification, ×200. Oil-red-O stain of NK2 transgenic mouse liver (C) at 48 h after PH. Note the presence of many small lipid droplets in hepatocytes. Magnification, ×400. BrdU stain of WT mouse liver (D) and NK2 transgenic mouse liver (E) at 48 h after PH. The arrows show hepatocytes undergoing DNA synthesis. Magnification, ×100. The BrdU labeling index of WT mice and NK2 transgenic mice at 48 h after PH (n = 30 per group). (F) Data are mean±SD of the mean. Hepatocyte proliferation was significantly reduced in NK2 transgenic mouse liver (^bP<0.01 vs WT mouse liver).