Effect of transjugular intrahepatic portosystemic shunt on pulmonary gas exchange in patients with portal hypertension and hepatopulmonary syndrome

Table 3 Pulmonary gas exchange and hemodynamics before and after TIPS placement in patients with HPS

	Pre-TIPS			Post-TIPS <1 mo			Post-TIPS >4 mo
Patients	# 1	# 2	# 3	# 1	# 2	# 3	# 1	# 2	# 3
FEV1 (% pred)	69	77	100
FVC (% pred)	66	77	113
FEV1/FVC	77	80	82
TLC (% pred)	68	70	83
DLCO (% pred)	21.3	24	8
PaO2 (mmHg)	32	59	28	58	61	31	33	34	–
PaCO2 (mmHg)	27	28	35	31	27	38	26	34	–
AaPO2 (mmHg)	88	54	78	53	69	71	87	73	–
PaO2 100% O2 breathing (mmHg)	64	606	86	–	–	–	–	–	–
PAP (mmHg)	14.5	9	18	–	8	22	20	8	–
PVR (dyn.s/cm5)	49	31	111	–	21	82	38	18	–
SVR (dyn.s/cm5)	773	415	1 174	–	400	922	549	560	–
QT (L/min)	9.0	10.4	6.47	–	11.2	7.8	10.5	11.3	–
PP (mmHg)	22	16	19	14	11	22	18.5	11	–
IVCP (mmHg)	5	4	3	7	2.5	19	8	2.5	–
PPG (mmHg)	17	12	16	7	8.5	3	10.5	8.5	–

FEV₁: forced expiratory volume at 1 s; FVC: forced vital capacity; TLC: total lung capacity; DL_CO: single-breath carbon monoxide diffusing capacity; PaO₂: partial pressure of arterial oxygen; PaCO₂: partial pressure of arterial carbon dioxide; AaPO₂: alveolar to arterial oxygen partial pressure gradient; PAP: mean pulmonary artery pressure; PVR: pulmonary vascular resistance; SVR: systemic vascular resistance; Q_T: cardiac output; PP: portal pressure; IVCP: inferior vena cava pressure; PPG: portocaval pressure gradient.