Immunological treatment of liver tumors

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 11, Issue 42

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

All Articles published online

Item

Count

PDF

378

HTML

2509

Figures (1-1)

148

Tables (1-2)

138

Sum=3173

Nov 14, 2005 (publication date) through Apr 24, 2024

Times Cited of This Article

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Gastroenterol. Nov 14, 2005; 11(42): 6571-6576
Published online Nov 14, 2005. doi: 10.3748/wjg.v11.i42.6571

Table 2 Commonest viruses used as gene therapy vectors

Retroviruses	Adenoviruses	Adeno-associated virus (AAV)	Herpes virus
8kb, RNA enveloped	35 kb, DNA, non-enveloped	5 kb, single stranded DNA, non-enveloped	61 kb, double-stranded DNA
Activate proto-oncogene by insertional mutagenesis	Episomal, transient	Stable integration, high infectivity	Infect mainly neurons
Cause lymphoma	Highly immunogenic, causing inflammation and anaphylactic shock	Non-pathogenic; requires helper viruses such as Adenoviruses for replication and packaging in mammalian cells.	Cause cold sores or blisters in the genital areas
Inactivation of transgene in vivo	One case of death	Long-term expression in vivo	Cutaneous skin lesions

Citation: Chiriva-Internati M, Grizzi F, Jumper CA, Cobos E, Hermonat PL, Frezza EE. Immunological treatment of liver tumors. World J Gastroenterol 2005; 11(42): 6571-6576
URL: https://www.wjgnet.com/1007-9327/full/v11/i42/6571.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i42.6571