Differential effects of glutamate receptor antagonists on dorsal horn neurons responding to colorectal distension in a neonatal colon irritation rat model

Figure 3 Effect of spinal AP7 on average responses of LS neurons to CRD. Bar graphs illustrate the responses of LS neurons to CRD (20-80 mmHg) recorded in control rats (A; left panel) or CI rats (B; right panel) before and after spinal administration of AP7. A: AP-7 (0.1 mmoL) significantly attenuated the average response to high intensity CRD (80 mmHg) and AP-7 (1 mmoL) significantly attenuated the responses to CRD (40-80 mmHg) in controls; B: AP-7 (0.01 mmoL) significantly attenuated the average responses to graded CRD in CI rats in a dose-dependant manner. ^aP<0.05, ^bP<0.01, ^dP<0.001 vs before AP-7 application at that distention pressure in each group.