Grapefruit-seed extract attenuates ethanol-and stress-induced gastric lesions via activation of prostaglandin, nitric oxide and sensory nerve pathways

Figure 5 Effect of GSE (32 mg/kg ig) on the mean area of ethanol-induced gastric lesions and accompanying alterations in the GBF in rats with or without capsaicin inactivation of sensory nerves. Results are mean±SE from 6–8 animals per group. ^aP < 0.05 vs vehicle (Veh), ^bP < 0.01 vs respective values in animals without capsaicin denervation, ^cP < 0.05 vs respective values in animals with capsaicin denervation. administration, ^cP < 0.05 vs respective values in animals treated with L-NNA. vs vehicle (Veh), ^bP < 0.01 vs respective values in animals without indomethacin or rofecoxib pretreatment.