Grapefruit-seed extract attenuates ethanol-and stress-induced gastric lesions via activation of prostaglandin, nitric oxide and sensory nerve pathways

Figure 4 Effect of GSE (32 mg/kg i. g.) on the mean number of WRS-induced gastric lesions and accompanying alterations in the GBF in rats with or without the pretreatment with L-NNA (20 mg/kg i.p.). Results are mean ±SE from 6-8 animals per group. ^aP < 0.05 vs vehicle (Veh), ^bP < 0.01 vs respective values in animals without L-NNA administration, ^cP < 0.05 vs respective values in animals treated with L-NNA. vs vehicle (Veh), ^bP < 0.01 vs respective values in animals without indomethacin or rofecoxib pretreatment.