Differential effects of glutamate receptor antagonists on dorsal horn neurons responding to colorectal distension in a neonatal colon irritation rat model

doi:10.3748/wjg.v11.i41.6495

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Nov 7, 2005 (publication date) through May 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 7, 2005; 11(41): 6495-6502
Published online Nov 7, 2005. doi: 10.3748/wjg.v11.i41.6495

Table 2 Percentage attenuation of responses to graded CRD of LS neurons by CNQX in control and CI rats

Dose	20 (%)	40 (%)	60 (%)	80 (mmHg%)
Controls
0.2 μmoL	23.5 (4/17)	23.5 (4/17)	23.5 (4/17)	23.5 (4/17)
2 μmoL	44.4 (4/9)	44.4 (4/9)	44.4 (4/9)	44.4 (4/9)
5 μmoL	50 (4/8)	62.5 (5/8)	62.5 (5/8)	62.5 (5/8)
10 μmoL	71.4 (5/7 )	75 (6/8)	75 (6/8)	75 (6/8)
CI rats
0.2 μmoL	45.4 (5/11)	45.4(5/11)	45.4 (5/11)	45.4 (5/11)
2 μmoL	77.8 (7/9)	77.8 (7/9)	77.8 (7/9)	77.8 (7/9)
5 μmoL	83.3 (5/6)	83.3 (5/6)	83.3 (5/6)	83.3 (5/6)
10 μmoL	100 (8/8 )	100 (8/8 )	100 (8/8 )	100 (8/8 )

Denominators in parentheses indicate the total number of LS neurons treated with CNQX and numerators indicate the number of neurons affected by CNQX at the same dose level in control and CI rats. The effect of CNQX on neuronal response to all intensities of CRD was more pronounced in CI rats than that in control rats. CNQX dose-dependently attenuated the CRD-evoked responses at all distention pressures in all 8 (100%) CI neurons.

Citation: Lin C, Al-Chaer ED. Differential effects of glutamate receptor antagonists on dorsal horn neurons responding to colorectal distension in a neonatal colon irritation rat model. World J Gastroenterol 2005; 11(41): 6495-6502
URL: https://www.wjgnet.com/1007-9327/full/v11/i41/6495.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i41.6495