Classification tool for the systematic histological assessment of hepatocellular carcinoma, macroregenerative nodules, and dysplastic nodules in cirrhotic liver

Table 2 MCA of the values of the histological variables in the three categories (HCC, MRN, and DN) in the exploratory set of 212 hepatocellular nodules in cirrhotic livers

Position	Feature	Grade	HCC number (total 106)	%	DN number (total 32)	%	MRN number (total 74)	%
1	Vascular invasion	Present	27	25.5	0	0	0	0
2	Necrosis	Present	17	16	0	0	0	0
3	Capsular invasion	Present	44	41.5	0	0	0	0
4	Cellular atypia	4-5	30	28.3	0	0	0	0
5	Trabecular thickness	>4	35	33	1	3	0	0
6	Mitosis	Any	50	47.2	0	0	0	0
7	Reticulin loss	4-5	47	44.3	0	0	0	0
8	Capillarization	5	56	52.8	0	0	0	0
9	Cellular atypia	3	38	35.8	0	0	0	0
10	Solitary arterioles	>2	23	21.7	1	3	1	1
11	Trabecular thickness	4	27	25.5	3	9	0	0
12	Capillarization	4	27	25.5	1	3	0	0
13	Solitary arterioles	2	37	34.9	5	15	1	1
14	Heterogeneity	Present	100	94.3	23	72	5	7
15	Reticulin loss	1-3	56	52.8	9	28	2	3
16	Solitary arterioles	1	33	31.1	7	22	10	14
17	Capillarization	3	19	17.9	8	25	2	3
18	Trabecular thickness	<4	44	41.5	27	84	72	97
19	Cellular atypia	1-2	37	34.9	12	38	16	22
20	Necrosis	Not present	89	84	32	100	74	100
21	Vascular invasion	Not present	79	74.5	32	100	74	100
22	Capsular invasion	Not present	62	58.5	32	100	74	100
23	Mitosis	Not present	56	52.8	32	100	74	100
24	Solitary arterioles	<1	13	12.3	19	59	62	84
25	Capillarization	0–2	4	3.8	23	72	72	97
26	Cellular atypia	0	1	0.9	20	63	58	78
27	Heterogeneity	Not present	6	5.7	9	28	69	93
28	Reticulin loss	0	3	2.8	23	72	72	97

Position = This means the position of each variable in “malignancy scale” as shown in Figure 2, i.e. position number 1 = left side of the chart (higher “degree of malignancy”) and position 28 = right side of the chart (lower degree of malignancy).