Brief Reports
Copyright ©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Jan 28, 2005; 11(4): 587-592
Published online Jan 28, 2005. doi: 10.3748/wjg.v11.i4.587
Table 1 Cathepsins B, L and their inhibitor activities, survival time and the total cure responses of hepatoma morris-5123 in Wistar rats before and after treatment in comparison with negative control (median, mean±SD, range).
Cathepsins B, L(mEU/mg)Inhibitor (CPI80)(mEU/mg)Inhibitor (CPI37)(mEU/mg)Complex form (△CPI) (mEU/mg)Survival time (d)Cure(yes/No)Value(P)
Control negative5.824.710.514.2
(healthy)6.5±1.725.4±8.911.2±2.814.2±6.16010/100.0005
(2.4-8.2)(12.6-40.7)(2.4-14.5)(10.2-26.2)
Control positive88.517.58.5909–12
(Tumor)85.4±12.618.8±8.69.3±1.29.5±7.4-10.52/100.0001
(10.5-123.9)(4.6-23.8)(1.4-12.5)(3.2-11.3)
Tumor+ 10 mg Vit E80.528.716.412.312-26
81.8±20.629.5±12.017.0±5.512.5±6.5-192/100.0005
(11.0-99.8)(6.7-35.7)(3.9-20.3)(2.8-15.4)
Tumor+20 mg Vit E78.735.620.315.315-30
79.4±20.436.6±15.021.5±4.615.1± 10.4-22.53/100.0005
(10.7-97.4)(7.3-40.1)(4.2-22.0)(3.1-18.1)
Tumor+ 200 μg CPI56.546.335.810.516-30
57.4±15.147.7±20.037.0±17.610.7±2.4-233/100.0001
(22.1-80.6)(12.3-52.9)(9.0-40.0)(3.3-12.9)
Tumor+ 400 μg CPI47.967.846.82118-35
48.7±18.669.0±25.247.3±16.021.7±9.2-21.54/100.0001
(23.2-68.9)(20.6-88.5)(14.4-60.1)(6.2-28.4)
Tumor+ 10 mg Vit E +Tumor+ 200 µg CPI41.871.852.318.527-38
43.0±10.673.0±25.453.6±22.119.4±3.3-32.54/100.0001
(12.0-46.7)22.7-82.8(20.4-63.3)(2.3-11.5)
Tumor+ 10 mg Vit E +Tumor+ 400 µg CPI30.282.26121.230-40
31.6±12.083.5±29.862.4±25.521.1±4.3-355/100.0001
(9.8-38.7)(26.9-93.7)(24.6-70.2)(2.3-23.5)
Tumor+ 20 mg Vit E +Tumor+ 200 µg CPI15.494.474.210.238-60
16.5±2.895.8±35.475.6±33.110.2±2.3-496/100.0001
(6.4-20.8)(37.8-112.7)(32.3-94.5)(5.5-18.2)
Tumor+ 20 mg Vit E+Tumor+ 400 µg CPI7.5120.8105.515.345-60
8.4±1.8122.0±43.6107.0±39.215.0±4.4-52.57/100.0001
(2.6-10.2)(45.8-135.5)(35.6-118.2)(10.2-17.3)