Pituitary adenylate cyclase activating-peptide and its receptor antagonists in development of acute pancreatitis in rats

Table 7 Histological scoring (effect of PACAP receptor antagonists) (mean±SE).

Group	Hemorrhage	Parenchymal necrosis	Vacuolization	Inflammatory infiltration
Caerulein-induced pancreatitis			1.67±0.60	2.5±0.22
Sodium taurocholate-induced pancreatitis	1.5±0.67	2.5±0.49	0.5±0.49	3
10 μg PACAP6-27				1.5±0.5
100 μg PACAP6-27				0.83±0.54
Caerulein+10 μg PACAP6-27	0.83±0.54	0.17±0.17	1.83±0.60	2.5±0.5
Caerulein+100 μg PACAP6-27	1.67±0.49	1±0.52	2.17±0.31	2.5±0.22
Sodium taurocholate+10 μg PACAP6-27	1.5±0.67	3	1.33±0.61	3
Sodium taurocholate+100 μg PACAP6-27	1.5±0.5	2.83±0.17	2±0.52	3
10 μg (4-Cl-D-Phe6, Leu17) VIP			0.33±0.33	2±0.63
100 μg (4-Cl-D-Phe6, Leu17) VIP			1±0.63	1.67±0.60
Caerulein+10 μg (4-Cl-D-Phe6, Leu17) VIP	0.17±0.17	0.17±0.17	0.67±0.40	2±0.51
Caerulein+100 μg (4-Cl-D-Phe6, Leu17) VIP	0.33±0.33	1.67±0.49	2.17±0.48
Sodium taurocholate+10 μg (4-Cl-D-Phe6, Leu17) VIP	1.5±0.56	2.5±0.49	1.17±0.60	3
Sodium taurocholate+100 μg (4-Cl-D-Phe6, Leu17) VIP	1.5±0.67	2.33±0.33	1.83±0.60	3