Endothelin-1 stimulates contraction and migration of rat pancreatic stellate cells

Figure 6 ET-1 did not alter basal or inducible proliferation of PSCs. Serum-starved PSCs were treated with ET-1 at 0 or 100 nmol/L in the absence or presence of PDGF-BB (at 25 mg/L) or 100 mL/L fetal bovine serum ("FBS". After 24-h incubation, DNA synthesis was assessed by BrdU incorporation enzyme-linked immunosorbent assay. Data are shown as mean±SD (n = 6). NS: not significant, A: optical density.