Preventative effects of a probiotic, Lactobacillus salivarius ssp. salivarius, in the TNBS model of rat colitis

doi:10.3748/wjg.v11.i33.5185

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 7, 2005; 11(33): 5185-5192
Published online Sep 7, 2005. doi: 10.3748/wjg.v11.i33.5185

Table 4 Myeloperoxidase (MPO) activity, total GSH content, TNF-α and LTB4 levels in colon specimens from non-colitic rats, TNBS control colitic rats and TNBS colitic rats treated with L. salivarius ssp. salivarius (5×10⁸ CFU/rat·d)

Group (n = 10)	MPO activity (units MPO/g)	GSH (nmol/g)	LTB₄ (ng/g)	TNF-α (pg/g)
Non-colitic	23.4±7.2	1 540±41	2.9±0.4	441.5±39.1
TNBS control	180.6±21.9^d	1 087±51^d	6.5±0.9^d	782.9±60.1^d
TNBS probiotic	105.3±26.0^a^d	1 252±42^a^d	6.9±0.8^d	509.4±68.2^b

Data are expressed as mean±SE.

^aP<0.05,

^bP<0.01 vs TNBS control group;

^dP<0.01 vs non-colitic group.

Citation: Peran L, Camuesco D, Comalada M, Nieto A, Concha A, Diaz-Ropero MP, Olivares M, Xaus J, Zarzuelo A, Galvez J. Preventative effects of a probiotic, Lactobacillus salivarius ssp. salivarius, in the TNBS model of rat colitis. World J Gastroenterol 2005; 11(33): 5185-5192
URL: https://www.wjgnet.com/1007-9327/full/v11/i33/5185.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i33.5185