Gene expression profiles in peripheral blood mononuclear cells of SARS patients

Table 5 Differentially expressed genes encoding pro- and anti-inflammatory cytokines are involved in IL-1 and TNF-α signaling cassettes in two patients

GenBank access	Definition	P1	P2
Pro- and anti-inflammatory cytokines and receptors
AF043337	IL-8	8	–2.46
NM_000634	IL-8 receptor, α	73.52	–
NM_001557	IL-8 receptor, β	51.98	4.29
NM_000575	IL-1, α	3.73	–
NM_000576	IL-1, β	6.5	11.31
NM_000877	IL-1 receptor, type I	18.38	–
NM_004633	IL-1 receptor, type II	362.04	3.84
U64094	Soluble type II IL-1 receptor	630.35	–
NM_003856	IL-1 receptor-like 1	11.31	3.25
U65590	IL-1 receptor antagonist IL-1Ra	14.93	–
AF051151	Toll/IL-1 receptor-like protein 3	14.93	–
NM_000418	IL-4 receptor	13.93	–
NM_000600	IL-6	–	3.03
NM_002184	IL-6 signal transducer gp130	–	–2.14
BC001903	IL-10 receptor, β	4	–
NM_004512	IL-11 receptor, α	–6.06	–2.30
NM_001560	IL-13 receptor, α1	3.25	–
U62858	IL-13 receptor	5.66	–
U81380.2	IL-13 receptor soluble form	4.29	–
NM_000585	IL-15	–3.03	2
NM_004513	IL-16	–	–2.83
NM_014339	IL-17 receptor	4.29	–
NM_003855	IL-18 receptor 1	42.22	–
NM_003853	IL-18 receptor accessory protein	19.7	–
AF269133	Novel interleukin receptor	–3.03	–
NM_004862	TNF-α	17.15	–
NM_001065	TNFRSF1A	4	–
NM_003841	TNFRSF10C	19.7	–
NM_000760	G-CSF 3 receptor	25.99	–
BC002635	GM-CSF 2 receptor, α, low-affinity	3.03	–
M64445	GM-CSF receptor	4.92	2.64
NM_002607	Platelet-derived growth factor α polypeptide	–2.46	–
NM_004347	Caspase 5	4.59	–
NM_000201	Intercellular adhesion molecule 1	17.15	–
NM_002162	Intercellular adhesion molecule 3	6.28	–
NM_003243	Transforming growth factor, β receptor III	–36.76	–4.59
NM_003242	Transforming growth factor, β receptor II	–	–2.30
NM_000358	Transforming growth factor, β-induced, 68 ku	–24.25	–
The genes involved in the IL-1 signaling pathway
NM_007199	IL-1 receptor-associated kinase M	19.7	–
NM_002182	IL-1 receptor accessory protein	25.99	–
AF167343	Soluble IL-1 receptor accessory protein	55.72	–
M87507	IL-1 β convertase	3.25	–
U13698	IL-1-β converting enzyme isoform γ	3.03	–
U13699	IL-1-β converting enzyme isoform δ	–	2.14
U13700	IL-1-β converting enzyme isoform ε	2.64	–
The TNF signal downstream genes
NM_004619	TNF receptor-associated factor 5	–	–2.00
NM_016614	TRAF and TNF receptor-associated protein	3.84	–2.30
NM_006290	TNF-α induced protein 3	5.66	–
NM_007115	TNF-α induced protein 6	45.25	4.92
AB034747	Small integral membrane protein of lysosome late endosome	7.46	–
U50062	RIP protein kinase	–	–2.00