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World Journal of Gastroenterology
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1007-9327
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Viral Hepatitis
©The Author(s) 2005.
World J Gastroenterol. Aug 14, 2005; 11(30): 4703-4708
Published online Aug 14, 2005. doi: 10.3748/wjg.v11.i30.4703
Table 3 Summary of the biological impact of “hot-spot” mutations on genotype B and C HBx
HBx mutantsGenotype B1
Genotype C2
TransactivationAntiproliferationTransactivationAntiproliferation
I127T↑3↑↑-5
I127T+K130M+V131I↑↑--
K130M+V131I↓4↓-↓
K130M+V131I+F132Y↓↓-↑
F132Y↓↓-↓
1Changes of biological functions were compared with XB;
2Changes of biological functions were compared with XC. 3,4,and5 accordingly indicate increased, decreased and equal activities of HBx mutants as compared with XB/XC.
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