Effect of lipopolysaccharide on diarrhea and gastrointestinal transit in mice: Roles of nitric oxide and prostaglandin E2

Table 5 Effects of L-NAME or/and arginine on lipopolysaccharide (LPS)-induced diarrheogenic activity (mean±SE).

Treatment	Diarrheogenic activity (%)
Saline	0
LPS 20 mg/kg	87.7±4.0a
LPS 20mg/kg+L-NAME 10 mg/kg	40±4.36
LPS 20 mg/kg+L-NAME 20 mg/kg	30±4.46c
LPS 20 mg/kg+L-NAME 10 mg/kg +L-arginine 800 mg/kg	70±2.15
LPS 20 mg/kg+L-NAME 10 mg/kg +D-arginine 800 mg/kg	50±3.23
LPS 20 mg/kg+Indomethacin 10 mg/kg	30±4.25c
LPS 20 mg/kg+Indomethancin 20 mg/kg	20±2.41c
LPS 20 mg/kg+Indomethacin 15 mg/kg+L-arginine 800 mg/kg	50±3.62

^aP<0.05 vs the values in corresponding saline-treated mice,

^cP<0.05 vs the values in LPS (20 mg/kg)-treated mice.