Effect of lipopolysaccharide on diarrhea and gastrointestinal transit in mice: Roles of nitric oxide and prostaglandin E2

Table 2 Effects of L-NAME or indomethancin, and arginine on lipopolysaccharide (LPS)-induced gastrointestinal transit (GIT).

Treatment	Percent of GIT	% Inhibition of GIT
Saline	65.6±6.1	0
LPS 20 mg/kg	35.3±5.4a	43
LPS 20 mg/kg+L-NAME 10 mg/kg	56.7±6.9c	14
LPS 20 mg/kg+L-NAME 20 mg/kg	58.9±6.6c	10
LPS 20 mg/kg+L-NAME 10 mg/kg+L-arginine 800 mg/kg	44.2±6.5	33
LPS 20 mg/kg+L-NAME 10 mg/kg+D-arginine 800 mg/kg	55.6±6.2c	15
LPS 20 mg/kg+indomethacin 10 mg/kg	53.1±6.3c	22
LPS 20 mg/kg+indomethancin 20 mg/kg	57.6±5.7c	15
LPS 20 mg/kg+indomethacin 15 mg/kg+L-arginine 800 mg/kg	43.3±4.2	36
LPS 20 mg/kg+L-NAME 10 mg/kg+D-arginine 800 mg/kg	55.6±6.2c	15

^aP<0.05 vs the values of normal saline-treated mice,

^cP<0.05 vs the values of LPS alone-treated mice.