Pathological study of distal mesorectal cancer spread to determine a proper distal resection margin

Table 2 Comparison of clinicopathologic characteristics between patients with and without in distal mesorectum (mean±SD, n, %).

Parameters	With involvement (n = 8)	Without involvement (n = 37 )	P value
Age, mean±SD (yr)	61.7±19.4	63.4±12.5	NS
Gender			NS
Male	6 (75.0)	23 (62.2)
Female	2 (25.0)	14 (37.8)
Tumor location1			NS
Anterior	2 (25.0)	13 (35.1)
Lateral	3 (37.5)	10 (27.0)
Posterior	1 (12.5)	7 (18.9)
Circumferential	2 (25.0)	7 (18.9)
Distance of tumor from dentate line (cm)			NS
≤5	5 (62.5)	26 (70.3)
> 5	3 (37.5)	11 (29.7)
Patterns of tumor growth			NS
Infiltrating	6 (75.0)	28 (75.7)
Pushing	0 (0.0)	4 (10.8)
Mixed	2 (25.0)	5 (13.5)
Tumor maximal diameter (cm)			NS
≤5	5 (62.5)	22 (59.5)
>5	3 (37.5)	15 (40.5)
Tumor differentiation			NS
Well	2 (25.0)	9 (24.3)
Moderate	3 (37.5)	21 (56.8)
Poor	3 (37.5)	7 (18.9)
TNM stage2			NS
I	0 (0.0)	6 (16.2)
II	0 (0.0)	11 (29.7)
III	7 (87.5)	17 (45.9)
IV	1 (12.5)	3 (8.1)
Depth of tumor invasion			NS
T1	0 (0.0)	3 (8.1)
T2	0 (0.0)	11 (29.7)
T3	7 (87.5)	21 (56.8)
T4	1 (12.5)	2 (5.4)
Lymph node metastasis			0.043
Present	7 (87.5)	15 (45.9)
Absent	1 (12.5)	22 (54.1)
Distant metastasis during follow up			NS
Present	1 (12.5)	1(2.7)
Absent	7 (87.5)	36 (97.3)

NS = not significant.

¹Confirmation of tumor location according to more than two-thirds of tumor area within any side of rectal wall.

²According to the American Joint Committee on Cancer Staging Manual[14].