Sclerosing cholangitis following severe trauma: Description of a remarkable disease entity with emphasis on possible pathophysiologic mechanisms

Table 1 Summary of patients‘ characteristics

	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5
Sex	Female	Male	Male	Male	Male
Age (yr)	56	41	56	71	18
Initial event	Room fire	Motorbike accident	Tractor accident	Fall from a raised hide	Power current accident
					and fall
Injuries	Burn injury: 34 % of	Polytrauma with avulsions	Polytrauma with serial	Polytrauma with burst	Burn injury (36 % of body
	body surface (hands,	(left subclavian artery,	rib fracture, hemothorax,	fractures of lumbar spine,	surface), multiple rib
	head, neck, back)	forearm, anterior tibial	pleural effusion, fracture	paraplegia, rib fractures,	fractures, hemothorax,
		artery) and fractures	of right joint ankle	pneumothorax	fractures of the thoracic
		(left humeral shaft,			vertebrae 5 to 9
		pelvis, both lower legs)
Intensive care (d)	58	23	34	26	88
Time from	4	27	4	13	2
occurrence
of cholestasis until
diagnosis (mo)
Treatment start	mo 4	mo 22	mo 4	mo 13	mo 1
with UDCA
Follow-up(mo)	55 (death)	48	41	33	12
Complications	Liver cirrhosis (Child-	Small intrahepatic	unbearable pruritus	liver cirrhosis	-
	Pugh C), variceal	gallstones after 6 mo	during first year,	(Child-Pugh B),
	bleeding, death due	(endoscopically extracted),	liver cirrhosis	recurrent stomal
	to liver insufficiency	liver cirrhosis (Child-Pugh A)	(Child-Pugh A)	bleeding

UDCA: urso deoxycholic acid.