Familial gastric cancers with Li-Fraumeni Syndrome: A case repast

doi:10.3748/wjg.v11.i26.4124

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Jul 14, 2005 (publication date) through May 5, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 14, 2005; 11(26): 4124-4126
Published online Jul 14, 2005. doi: 10.3748/wjg.v11.i26.4124

Table 1 Definition of Li-Fraumeni syndrome and familial gastric cancer subtypes (familial gastric cancer, hereditary diffuse gastric cancer, and familial intestinal gastric cancer)

	Hereditary cancer	Definition	Reference
1	Li-Fraumeni syndrome (LFS)	A proband with a sarcoma under 45 yr	8
		Plus 1st degree relative under 45 yr with any cancer
		Plus an additional 1^st or 2^nd degree relative in the same lineage with
		any cancer aged under 45 yr or sarcoma at any age
2	Familial gastric cancer (FGC)	At least two gastric cancer patients within 1^st degree relatives	6
		and one patient diagnosed before the age of 50
2-(1)	Hereditary diffuse gastric cancer (HDGC)	(1) Two or more diffuse gastric cancer patients in 1^st or 2^nd degree relatives,	15
		with at least one diagnosed before the age of 50
		(2) Three or more diffuse gastric cancer patients in 1^st or 2^nd degree relatives,
		indepently of age of onset
2-(2)	Familail intestinal gastric cancer (FIGC)	At least three relatives should have intestinal gastric cancer and one of them	15
		should be a 1^st degree relative of the other two
		Plus at least two successive generations should be affected plus in one of the relatives, gastric cancer shoul be diagnosed before the age of 50

Criteria for countries with high incidence of gastric cancer.

Citation: Kim IJ, Kang HC, Shin Y, Yoo BC, Yang HK, Park JG. Familial gastric cancers with Li-Fraumeni Syndrome: A case repast. World J Gastroenterol 2005; 11(26): 4124-4126
URL: https://www.wjgnet.com/1007-9327/full/v11/i26/4124.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i26.4124