Adeno-associated virus mediated interferon-gamma inhibits the progression of hepatic fibrosis in vitro and in vivo

doi:10.3748/wjg.v11.i26.4045

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Jul 14, 2005 (publication date) through Apr 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 14, 2005; 11(26): 4045-4051
Published online Jul 14, 2005. doi: 10.3748/wjg.v11.i26.4045

Table 2 Serum markers of hepatic fibrosis and damage

	Number	Hydroxyproline	AST (U/L)	ALT (U/L)
	Number	(µg/g wet liver)	AST (U/L)	ALT (U/L)
No treatment	6	96 ± 11	76.3 ± 6.3	53.0 ± 6.9
CCl₄ (3 wk)	6	162 ± 14	561.2 ± 81.4	358.0 ± 85.4
CCl₄/Saline	8	236 ± 31	1 019.1 ± 276.3	770.5 ± 154.3
CCl₄/rAAV-eGFP	8	249 ± 37	985.4 ± 241.6	727.2 ± 175.0
CCl₄/rAAV-INF-γ	8	177 ± 28¹	668.5 ± 140.0²	458.4 ± 123.5³

Hydroxyproline content and serum AST, ALT are shown with mean ±SD for each group. There are no significant differences between group of CCl₄/saline and CCl₄/rAAV-eGFP in all three markers. The group of CCl₄/rAAV-INF-γ vs CCl₄/saline:

¹P = 0.0015;

²P = 0.0064;

³P = 0.0032.

Citation: Chen M, Wang GJ, Diao Y, Xu RA, Xie HT, Li XY, Sun JG. Adeno-associated virus mediated interferon-gamma inhibits the progression of hepatic fibrosis in vitro and in vivo. World J Gastroenterol 2005; 11(26): 4045-4051
URL: https://www.wjgnet.com/1007-9327/full/v11/i26/4045.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i26.4045