Review
Copyright ©The Author(s) 2005.
World J Gastroenterol. Jul 7, 2005; 11(25): 3817-3822
Published online Jul 7, 2005. doi: 10.3748/wjg.v11.i25.3817
Table 2 RCT studies on efficacy of systemic chemotherapy on prevention of recurrence
AuthorsTreatment protocolSample size(Tx/Ctl)ObservationtimeDFS Tx vs CtlOS Tx vs CtlConclusions
Lopez-Ladron et al[24]Surgery+post-operative38 (28/10)Median 15Median 15 vs 9Median 30vs15Not beneficial,
chemotherapy vs surgery alone(mo)(mo) (P = 0.352)(mo) (P = 0.066)needing further study
Portier et al[23]Surgery+post-operative162 (81/81)5 yr5-yr 33% vs 24%5-yr 51% vs 44%
chemotherapy (FU/FA) vs surgery alone(P > 0.05)(P > 0.05)Not beneficial