Increased proliferation activity measured by immunoreactive Ki67 is associated with survival improvement in rectal/recto sigmoid cancer

Table 3 Cox univariate and multivariate regression analysis.

Variable	Univariate analysis		Multivariate analysis
	HR (95%CI)	P	HR (95%CI)	P
Age (>65 vs <65 yr)	1.54 (0.99-2.39)	0.056	1.62 (1.04-2.52)	0.035
T-stage (3+4 vs 1+2)	2.24 (1.21-4.23)	0.010	1.61 (0.86-3.03)	0.139
N-stage (1+2+3 vs 0)	2.42 (1.57-3.74)	<0.001	1.82 (1.12-2.94)	0.015
Dukes (4 vs 1+2+3)	11.42 (5.342-4.43)	<0.001	6.32 (2.781-4.39)	<0.001
Ki67 (>40 vs ≤40)	0.63 (0.41-0.98)	0.040	1.26 (0.67-2.39)	0.469
Ki67 Hot spot (>50 vs ≤50)	0.48 (0.31-0.75)	0.001	0.51 (0.27-0.98)	0.044