Review
Copyright ©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. May 21, 2005; 11(19): 2851-2857
Published online May 21, 2005. doi: 10.3748/wjg.v11.i19.2851
Table 2 Antagonists of histamine receptors.
Receptor subtypeAntagonists
H1First-generation
Azatadine, clemastine, chlorpheniramine
(chlorphenamine maleate), diphenhydramine,
dexchlorpheniramine, hydroxyzine, mepyramine (pyrilamine), promethazine, terfenadine (teldane),
triprolidine[35-37]
Second-generation
Acrivastine[37,38], astemizole (hismanal)[38],
azelastine[38], cetirizine (virilx, zirtek, zyrtec)[39-41],
chlorpheniramine[42,43], desloratadine[44,45], ebastine[37,44],
emedastine[37], epinastine[41,46], homochlorcyclizine[47],
ketotifen[41,48] levocabastine[46], loratadine (claritin,
clarityne)[41,44,49], olopatadine[41,50], mequitazine[47],
mizolastine[47], pseudoephedrine[51,52], rupatadine[53,54],
tripelennamine (pyribenzamin)[55]
Third-generation
Fexofenadine[37,44,56], levocetirizine[37,39]
H2First-generation
Cimetidine[57], metiamide[58]
Second-generation
Ranitidine (1979)[59], omeprazole (1982)[60]
Third-generation
Famotidine[61], ebrotidine[62], lafutidine[63,64],
niperotidine[60], nizatidine[60], potentidine[65],
roxatidine[60], zolantidine[58]
H3A-304121[66], A-317920[66], 4-(aminoalkoxy)
benzylamines[67], ciproxifan[66], clobenpropit[68],
D-alanine-piperazine-amides[69], imidazopyridine[70],
indole[70], indolizine[70], 4’-[(NR1R2-1-yl)]-propoxy-
biaryl-4-carboxamides[70], pyrazolopyridine[71],
1-(4-(phenoxymethyl)benzyl) piperidines[72], SCH
79687[73], thioperamide[68,74],
H4JNJ 7777120[75,76], thioperamide[77]