Nitroester drug’s effects and their antagonistic effects against morphine on human sphincter of Oddi motility

Table 1 Manometric data before and after administration of GTN in 10 patients (mean±SD).

	Before GTN administration (control)	10 min after GTN administration	20 min after GTN administration
Sphincter of Oddi basal pressure (mmHg)	9.70±2.54	5.71±3.95a	5.80±3.42a
Amplitude of phasic contractions (mmHg)	88.84±68.77	52.07±23.59c	49.78±32.67c
Frequency of phasic contractions (n/min)	6.71±2.21	7.32±2.69	5.57±2.05
Common bile duct pressure (mmHg)	5.43±4.40	4.19±4.19	5.43±4.39

^aP<0.05,

^cP<0.05 vs themselves , n = 10 (n represent the number of patients involved in the research).