Effects of emodin and baicalein on rats with severe acute pancreatitis

Table 8 Pharmacodynamic comparation of emodin and baicalein[12-53].

Pharmacological function	Emodin	Baicalein
Antibiosis	Escherichia coli, Dysentery Bacillus. Aureus staphylococcus	G+,G- bacterium, fungi, spirilla
Anti-inflammation	Inhibiting inflammatory cytokine release, restraining vascular permeability, inhibiting leukotrienes synthesis	Anti-histamin release. anti-arachidonic acid metabolism, restraining vascular permeability, anti-allergy
Immunoregulation	Enhance immunity	(-)
Inhibiting pancreatin activity	Strongly suppressive effect on multiple pancreatins	Only on trypsogen
Protecting liver	Anti-hepatofibrosis, antagonzism of liver damage by CCL4	Anti-hepatofibrosis,
Protecting kidney	Inhibiting kidney compensative hypertrophy. Restraining proliferation of kidney fibroblast, preventing and curing earlier injury of kidney on rats with diabetes	(-)
Protecting pancreas	(+)	(-)
Cholagog	(+)	(-)
Diuresis	(+)	(+)
Antioxidation	(+)	(+)
Scavenging free-radicals	(+)	(+)
Anti-thrombosis	(+)	(+)
Circulatory system	Dilative effect on multiple blood vessel, depressing proliferation of vascular smooth muscle cell	Double effects of vasodilatation and vasoconstriction
Gastrointestinal tract	Double regulation of isolated intestine, anti-gastric ulcer,reducing gastric acid and pepsin, purgate	Curative effect on acute and chronic gastroenteritis
Anti-endotoxemia	(+)	(+)
Fever relieving	(–)	(+)

“+”for positive pharmacological action; “–”for negative pharmacological action.